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However, genetic association data cannot tell us how these variants influence the trait, or whether they influence the trait in the same way. We develop the NAvMix Noise-Augmented von Mises�Fisher Mixture model clustering method, which extends a directional clustering approach to include a noise cluster as well as a data-driven method for choosing the number of clusters. Based on the reviews, we will not be able to accept this version of the manuscript, but we would be willing to review a much-revised version. However, no such pathways were identified in the gene set analysis for Cluster 1.
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